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Have you heard about Pregnenolone?

Patients often ask us what they can do to improve their health. One way people can improve their health is to have good hormone balance. This can affect every aspect of your life. One often overlooked but critically important hormone is Pregnenolone. It is referred to as “The Mother Hormone” because it is the first hormone in the pathway that generates many other hormones. Pregnenolone is the main steroid produced in your body from cholesterol. It is produced by the brain, gonads(ovaries/testicles), and adrenal glands. It is a building block for many other steroid hormones including progesterone, DHEA, testosterone, and estrogen. Research has demonstrated several benefits to supplementing your body's natural pregnenolone production. It may help to improve depression, memory, sleep, weight loss, and even pain. Dementia treatment providers and pain management clinics often include Pregnenolone in their treatment plans. You can buy Pregnenolone supplement over-the-without a prescription. It is typically taken at a dose of 25 to 30mg once a day, although some studies have used much higher doses. As Pregnenolone can make you drowsy it is best to take it at night before bed.

You should not take Pregnenolone if you are pregnant or breastfeeding. Since pregnenolone can influence hormone levels, avoid using pregnenolone if you have or are at risk for hormone-sensitive conditions. Please consult your physician before starting any supplement or medication.

If you would like more information about Pregnenolone please contact our office or schedule a consultation with one of our experts today. To schedule an appointment please call Medical Specialty Clinic at 731 257-1500, email us at, or book an appointment online at

I have listed several references below that provide more detailed information about Pregnenolone.



  2. Akwa Y, Young J, Kabbadj K, et al. Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain. J Steroid Biochem Molec Biol. 1991. 40:71-81.

  3. Mechedlistvile Z and Kaper J. A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission. Mol Pharmocol. 2003. 64:857-64.

  4. Mayo W, LeMoal M, and Abrous DN. Pregnenolone sulfate and aging of cognitive functions: behavioral; neurochemical, and morphological investigations. Hormones and Behavior. 2001. 40:215-17.

  5. Manyam NVB, Katz L, Hare TA, et al. Levels of gamma-amino-butyric acid in cerebrospinal fluid in various neurologic disorders. Acad Neurol. 1980. 37: 352-55.

  6. Flood JF, Morley JE, and Roberts E. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: The amygdala is by far the most sensitive. Proc Natl Acad Sci. 1995. 92: 806-810.

  7. Ceccon M, Runbaugh G, and Vicini S. Distinct effect of pregnenolone sulfate on NMDA receptor subtypes. Neuropharmocol. 2001. 40: 491-500.

  8. Wu FS, Gibbs TT, and Farb DH. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol. 1991. 40 (3): 333-36.

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